Results remained significant in the younger subjects after adjustment for smoking, lipid profiles, fasting glucose, and resting blood pressure ( b=.024, P=.011) results also remained significant in a subgroup of unmedicated younger subjects without symptomatic cardiovascular disease (n=135 for SBP reactivity, b=.031, P=.036 for DBP, b=.037, P=.007).Ĭonclusions The tendency to show exaggerated pressor responses to mental stress is a significant independent correlate of atherosclerosis in this population sample of Finnish men. When examined separately by age, associations with IMT were significant only in the youngest half of the sample (age, 46 and 52 years, n=433 for mean IMT, DBP b=.033, P=.0002, SBP b=.0266, P=.003 for maximum IMT, DBP b=.039, P=.002, SBP b=.032, P=.011). Significant associations were also shown between stress-related systolic blood pressure (SBP) reactivity and mean IMT ( b=.0151, P=.042). Diastolic blood pressure (DBP) responses to mental stress were significantly associated with mean IMT ( b=.021, P=.006), maximum IMT ( b=.026, P=.013), and mean plaque height ( b=.017, P=.041). Ultrasound measures of intima-medial thickness (IMT) and plaque height from the common carotid arteries were used as noninvasive markers of atherosclerosis. Methods and Results 901 Eastern Finnish men from four age cohorts (age, 42 to 60 years) were administered a standardized testing battery to assess cardiovascular reactivity to mental stress. We examined this hypothesis using cross-sectional data from the Kuopio Ischemic Heart Disease study, a population-based epidemiological sample. Customer Service and Ordering Informationīackground Exaggerated cardiovascular reactivity to mental stress is hypothesized to increase atherosclerotic risk.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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